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Found 31 results.

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Mechanisms and clinical relevance of the GM-CSF chemical’s capacity to reverse C5a (complement)-mediated impairment of bacterial killing by neutrophils (white blood cells)

Patients in the intensive care unit (ICU) are at high risk of developing hospital infections. White blood cells (neutrophils) that destroy bugs work less efficiently in such patients. We can make these cells work again by adding a chemical (called GM-CSF) in the lab, but we don’t know how GM-CSF works or whether it might help in real patients. This proposal addresses these issues. When GM-CSF works, it probably turns on chemical ‘signals’ inside the white blood cell, which tell the cell to eat bugs more efficiently. I shall determine which chemical signals are turned on by GM-CSF. This will tell us how GM-CSF is working, and should suggest ways of developing new treatments to improve white cell function. I shall also study white blood cells from other patients who receive GM-CSF as part of their medical care. I shall determine whether GM-CSF makes white blood cells eat bugs more efficiently. If it does, the proposal would naturally lead on to clinical trials aiming to see if GM-CSF can prevent hospital infections in the ICU.

Author: Jim Macfarlane - Newcastle University



Development of a Questionnaire to Measure Service User Satisfaction Within In-Patient Forensic Services

The study consists of two parts, both conducted in forensic mental heath units. Part one uses focus groups to identify the important issues for service users in determining their level of satisfaction with services. Part two involves the testing of the reliability and validity of the questionnaire by the use of a cross sectional survey.

Author: Douglas MacInnes - Canterbury Christ Church University College

Tel: 01227 782787. Email:

Long term outcome following the treatment of bronchiolitis with Continuous Negative Extrathoracic Pressure (CNEP)

Children treated with CNEP at North Staffordshire Hospital (NSH) will be compared to matched children managed conventionally at Queen's in Nottingham.

Author: Neil Marlow - University College London

Tel: 020 7679 6056. Email:

The loss of family knowledge in Alzheimer's Disease.

A family member of the patient will be asked to give the names of family members (parents/grandparents/siblings/children/grandchildren) and some semantic information about people. The patient will be asked to recall the same information and then checked for their ability to recognise the names.

Author: Anna Marriott - Kingshill Research Centre Victoria Hospital

Tel: 01793 437598. Email:

Informing Carers: Exploring the relationship between carers, information and information providers.

Research was carried out with carers and information providers in Newcastle upon Tyne. A combined methodology of qualitative and quantitative methods was used, encompassing 3 research methods: postal questionnaire, focus group and one to one interviews. Carers were asked about their positive and negative experiences of finding, accessing and using information. Information providers were asked about their experiences of providing information for and to carers in respect of creating, defining and providing information, helping carers find information and barriers to information provision.

Author: Alexandra MARTIN - c/o Newcastle Carers Project

Tel: 0191 232 7445. Email:

RAPPORT: Research with Patient and Public Involvement: a Realist Evaluation

Stage 1: A national UK scoping has been undertaken of studies within the six exemplar research topics (cystic fibrosis, diabetes, arthritis, dementia, learning disability, public health) currently funded or completed within the last two years. Stage 2: Online survey has been undertaken of chief investigators leading studies in the six topic areas in four regions of England (London, East of England, NE and SW). Stage 3: Case studies: 23 research studies identified from the survey followed for over 18 months.

Author: Elspeth Mathie - University of Hertfordshire

Tel: 01707 281090. Email:


Wheelchair Skills Programme for Young People

The project revolves around young wheelchair users and the access they have to current training. At the moment wheelchair skills training for young people in Northern Ireland is limited. External organisations are sought for implementing training from mainland UK. Northern Ireland's Regional Wheelchair Training Occupational Therapist (OT) has independently designed a wheelchair skills training programme, which can be implemented and graded to suit the clients' needs. The programme will be adapted and implemented as a standardised and measurable wheelchair skills test initially, with a training programme to follow. This will hopefully standardise the level of training being given to all young wheelchair users, and improve services across Northern Ireland.

From the outset parents of young wheelchair users have been vocal in the lack of services for their children. In 2008 the "Proposals for Reform of Wheelchair Services 2008" was created to establish a greater structure to enhance services for wheelchair users, which was greatly influenced by service users and parents alike. It is this document that has meant our project has the evidence base to proceed to further enhance services in areas where it is much needed.

Without the voice of members of the public, friends, family of service users, this project would not exist, therefore thanks must go to them for speaking up.

Author: Adrienne McCann - Ulster University

Tel: 07783225353. Email:

Perception of impact of upper limb injuries sustained by manual wheelchair spinal cord injured patients

The study aims to look at the patient perspective of how upper limb injuries affect all aspects of life of those with a spinal cord injury (SCI), particularly in the case of manual wheelchair users who rely solely on their upper limbs for mobility. We will ask participants what services they have found useful and treatment they have availed of or are available to them. 

Author: Adrienne McCann - Ulster University

Tel: 07783225353. Email:

Qoh,FI - Quality of Life in Faecal Incontinence.

This study is multi-stage. First in two postal surveys, we are assessing the prevalence of faecal incontinence and the use of related aids and services. Second, quantitative interviews will be used to identify the impact of incontinence on quality of life and to generate content for a self-completion questionnaire. Finally the questionnaire will be tested and validated.

Author: Elaine McColl - Centre for Health Services Research, University of Newcastle

Tel: 0191 222 7260. Email:

Colitis Education and Support Programme (CESP)

This is an RCT of two approaches to delivery of education and support, to patients with UC, in an outpatient setting. Primary outcomes are emotional and social well-being as measured by quality of life scales. An economic evaluation is included.

Author: Elaine McColl - Centre for Health Services Research, University of Newcastle

Tel: 0191 222 7260. Email: