Search results

Found 1 results.

Searching for: Keyword - Immunisation

ESOS observational study of treatment outcome in early diffuse SSc

Systemic sclerosis (often termed scleroderma) is a rare multi-system connective tissue disease characterised by fibrosis, vascular abnormalities and immune dysfunction. People with the diffuse form of the disease (dcSSc) have a particularly aggressive form and are at high risk of developing lung, kidney and heart involvement with skin thickening spreading from the fingers, feet and face to involve upper arms, thighs or trunk. At present, there is no drug known to favourably influence disease course and both the rarity and severity of early dcSSc make it very difficult to conduct clinical trials. ESOS aims to compare the effectiveness of different immunosuppressant treatments currently favoured by clinicians in the early management of patients with early dcSSc in a prospective observational study, capturing entry and outcome data in a standardised way. Following informed consent, participating patients from centres across the world are followed up at set time-points and treated according to best clinical practice. The data collected will be compared using modern statistical techniques to determine which, if any, is the most effective treatment for early dcSSc.

Author: Holly Ennis - University of Manchester

Tel: 0161 275 1675. Email: holly.ennis@manchester.ac.uk

Website: www.ssc-esos.net