Research project
Title: A Large, Randomised Long-Term Assessment of the Relative Cost-Effectiveness of Surgery for Parkinson's Disease.
Project timescale: From 01 April, 2001 to 01 March, 2010
(Added to website on: 18 May, 2001 - Date last updated: 11 October, 2007)
Source of funding:
Medical Research Council/Parkinson's Disease Association (UK)
Aims: To evaluate the cost-effectiveness of subthalamic nucleus surgery and also the timing of surgery, compared with active medical therapy.
Research designs used:
Randomised controlled trial
Methods used to collect data:
Validated instruments eg Outcome measures
Research project description: An open RCT of early surgery ( STN stimulation or lesioning) versus medical therapy (often using continuous apomorhpine) with surgery deferred for as long as possible. Primary outcome measure is PDQ-39, a patient orientated PD-specific health-related quality of life instrument. Setting will be in neurology and neurosurgical units of major hospitals.
Stages at which the public were involved:
Disseminating research
Implementing action
Prioritising topic areas
Other: Funding the research, PDS Representative on Trial Steering Committee.
Description of public involvement in research stages: Parkinson's Disease Society (PDS) conditional funding if Medical Research Council peer-reviewed application successful; PDS facilitated discussion at DOH; involvement of PD Nurse specialist network.
Training and support provided for either members of the public or researchers involved in the project:
Examples of ways the public have made a difference to the research project: PDS support emphasises the focus of the research is on patient reported quality of life in addition to clinical measurements; hopefully, financial and strategic backing will secure MRC (or other) funding.
Evaluating the impact of public involvement in the research:
Details of publications or reports resulting from the research: No publications yet. Trial opened in pilot Dec 2000 and will open main phase June 2001
Was/is your project user controlled: Not Known
For further information on the project, please contact:
University of Birmingham Clinical Trials Unit
Park Grange
1 Somerset Road
Edgbaston
Birmingham
B15 2RR
PD-TRIALS@ bham.ac.uk
0121 687 2314
Website: http://www.bctu.bham.ac.uk
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