Description The prevalence of liver disease is rising due to increases in hepatitis C virus (HCV) infection, alcohol use and obesity. This inflammation leads to further damage to the liver causing cirrhosis and liver cancer (hepatocellular carcinoma). Researchers at the University of Birmingham and University Hospital Birmingham NHS Foundation Trust have been analysing molecular cells to obtain a better understanding of why problems occur in the liver so that they can help to identify areas where treatment is likely to be more effective for patients with liver disease. The Centre for Liver Research has been at the forefront of research into the causes of liver disease for over 15 years. Since 2008 the Centre has been a National Institute for Health Research (NIHR) Biomedical Research Unit (NIHR Birmingham Liver BRU). The NIHR BRU works in collaboration with scientists, both in the United Kingdom and worldwide, on clinical trials to take research from the laboratory directly to the patient’s bedside as part of new treatment options for patients with liver disease. We also work closely with Pharmaceutical companies to develop new treatments or improve existing ones for these group of patients.