The degree to which a medicine is poisonous. How much of a medicine can be taken before it has a toxic effect.
Activities carried out to identify suitable topics for research. These activities provide a way for individuals and groups to propose areas where good evidence is lacking or unanswered questions exist.
A call for proposals in a particular area of medicine or health (e.g. obesity, dementia).
A systematic assessment of an intervention (or group of interventions), usually undertaken for policy customers such as NICE.
School for Social Care Research
Systematic Reviews Programme
School for Public Health Research
School for Primary Care Research
A substantial amendment can be defined as an amendment to the protocol or any other study specific documentation, the terms of the REC application or the terms of the CTA application (as applicable) that is likely to affect to a significant degree the: The safety or physical or mental integrity of the subjects of the …
Site Specific Information: local detail to inform SSA including qualifications/expertise of the PI and wider research team, study procedures, departmental capacity to absorb project (includes Pharmacy, Pathology, Radiology) and departmental leads signatures; The SSI form is completed in IRAS
Site Specific Assessment: An assessment performed to establish the suitability of a Principal Investigator and a site for the conduct of research; SSA will be performed by the Participating CLRN for each research site (NHS organisation), using an SSI form available in IRAS
Stroke Research Network