Evidence Library

Title: Impact of patient and public involvement on enrolment and retention in clinical trials: systematic review and meta-analysis.
Author: Crocker J, Ricci-Cabello I, Servet M, Parker A, Hirst J, Chant A, Petit-Zeman S, Evans D, Rees S.
Date Published: 2018
Reference: BMJ 363:k4738
Are service users or carers authors: Yes

Abstract: Aim: To investigate the impact of patient and public involvement (PPI) on rates of enrolment and retention in clinical trials and explore how this varies with the context and nature of PPI. Methods: Systematic review and meta-analysis. Results: 26 studies of the impact of involvement on recruitment were included in the review. The PPI had been carried out in different ways, involving different numbers and types of people, and at different stages of the research. On average, PPI modestly but significantly increased the enrolment to clinical trials. The involvement of people with lived experience of the condition under study had a bigger impact. There weren’t enough studies of whether involvement made it more likely participants would stay to the end of a trial to be able to assess this impact. Conclusions: The authors conclude that these findings strengthen the case for PPI in clinical trials. Further research is needed to assess which approaches work best, whether PPI is cost-effective, and whether involvement at an earlier stage of trial design makes a bigger difference.

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Categories: all
impact on research
impact of public involvement
journal article

Date Entered: 2018/11/30

Date Edited: 2018/11/30

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